preparation and quality control of scandium-46 bleomycin as a possible therapeutic agent

نویسندگان

leila moghaddam-banaem

amir reza jalilian

mohammadreza pourjavid

ali bahrami-samani

mohammad mazidi

چکیده

introduction: due to interesting therapeutic properties of 46sc and antineoblastic antibiotic, bleomycin (blm), 46sc-bleomycin (46sc-blm) was developed as a possible therapeutic compound. methods: in this work, sc-46 chloride was obtained by thermal neutron flux (4 × 1013 n.cm-2.s-1) of natural metallic scandium sample followed by dissolution in acidic media  as a substitute for 47sc in radiolabeling studies which was further used for labeling of bleomycin (blm) followed by stability studies as well as biodistribution in wild-type rats. results:  sc-46 was obtained in high radiochemical purity (itlc, >99%, two systems) as well as acceptable specific activity. at optimized conditions a radiochemical purity of 98% was obtained for 46sc-blm shown by itlc (specific activity, 740 gbq/mmole). the accumulation of the radiolabeled compound in lungs, liver and spleen demonstrates a similar pattern to the other radiolabeled bleomycins. conclusion: sc-blm is a possible therapeutic agent in human malignancies and the efficacy of the compound should be tested in various tumor-bearing models.

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عنوان ژورنال:
iranian journal of nuclear medicine

ناشر: tehran university of medical sciences

ISSN 1681-2824

دوره 20

شماره 1 2012

کلمات کلیدی
[ ' b l e o m y c i n ' , ' s c ' , 4 6 , ' b i o d i s t r i b u t i o n ' , ' r a d i o l a b e l i n g ' ]

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